Skip to main content

Unmasking of Brugada Syndrome Type 1 from Lithium Administration

Unmasking of Brugada Syndrome Type 1 from Lithium Administration

Ethan Swartz1*, Navid Radfar1, Harsh Singh1, Serin Varughese1, Eugene Kim1, Meet Shah2, Eison de Guzman2, Delia Cotiga3 and Renjit Thomas3

1Department of Internal Medicine, Rutgers New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA
2Division of Cardiology, Department of Medicine, Rutgers New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA
3Department of Cardiology, VA New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ, USA

*Corresponding author: Ethan Swartz, Department of Internal Medicine, Rutgers New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA.
E-mail: es1398@njms.rutgers.edu

Received: July 16, 2026; Accepted: August 03, 2026; Published: August 15, 2026

Citation: Swartz E, Radfar N, Singh H, et al. Unmasking of Brugada Syndrome Type 1 from Lithium Administration. Case Rep Clin Cardiol J. 2026; 6(4): 187.

Abstract

Brugada syndrome (BrS) is an inherited cardiac channelopathy associated with characteristic electrocardiographic (ECG) changes and an increased risk of sudden cardiac death (SCD). These ECG findings are often concealed and may be unmasked by sodium channel blocking agents. Lithium, a first-line mood stabilizer for bipolar disorder, exerts clinically relevant cardiac sodium channel blockade, though its association with BrS is infrequently reported. We describe a case of a 28-year-old male with bipolar disorder type I who presented with chest pain and was found to have a type 1 Brugada ECG pattern while taking lithium therapy. Following discontinuation of lithium and transition to aripiprazole, repeat ECG one year later demonstrated resolution of the Brugada pattern. Given lithium’s widespread use and the transient nature of drug-induced Brugada patterns, heightened clinical awareness is essential to avoid misdiagnosis and mitigate arrhythmic risk.

https://www.cardiologycasereportsjournal.org/archive/Unmasking-of-Brugada-Syndrome-Type-1-from-Lithium-Administration.html

Labels:
Location: United States

Comments

Post a Comment

Popular posts from this blog

Totally Implanted Venous Catheter: What Can Go Wrong

Totally Implanted Venous Catheter: What Can Go Wrong Marisa C. Couto * , Nuno Teixeira Tavares and Miguel Barbosa Serviço de Oncologia Médica, Unidade Local de Saúde de São João; Porto, Portugal * Corresponding author:  Marisa C. Couto, Serviço de Oncologia Médica, Unidade Local de Saúde de São João; Porto, Portugal. E-mail:  coutomarisa18@gmail.com Received:  July 20, 2025;  Accepted:  August 02, 2025;  Published:  August 15, 2025 Citation:  Couto MC, Tavares NT, Barbosa M. Totally Implanted Venous Catheter: What Can Go Wrong? Clin Image Case Rep J. 2025; 7(5): 569. Abstract A 50-year-old woman with a BRCA1 mutation was diagnosed with triple-negative carcinoma of the left breast in 2022. To initiate neoadjuvant chemotherapy, a totally implanted subclavian catheter was inserted. After three months of use, it developed a thrombosis and had to be removed. A second catheter was then inserted into the left brachial vein. Immediately after placement, t...
Post a Comment
Read more

Adenoid Cystic Carcinoma of the Breast: A Multi-institutional Case Series and Review of Literature

Adenoid Cystic Carcinoma of the Breast: A Multi-institutional Case Series and Review of Literature Rachel Dileo 1* , Vinay Edlukudige Keshava 3 , Sumukh Arun Kumar 3 , Rajesh Thirumaran 4  and Christie Hilton 2 1 Allegheny Health Network Internal Medicine Department, Pittsburgh, PA, USA 2 Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA 3 Bayhealth Medical Center, Dover, DE, USA 4 Mercy Catholic Medical Center, Darby, PA, USA * Corresponding author:  Rachel Dileo, Allegheny Health Network Internal Medicine Department, Pittsburgh, PA, USA. E-mail:  rachel.dileo2@ahn.org Received:  July 09, 2025;  Accepted:  July 26, 2025;  Published:  August 15, 2025 Citation:  Dileo R, Keshava VE, Kumar SA, et al. Adenoid Cystic Carcinoma of the Breast: A Multi-institutional Case Series and Review of Literature. J Breast Cancer Case Rep. 2025; 1(1): 101. https://www.salfordpublishers.org/jbccr/Adenoid-Cystic-Carcinoma-of-the-Breast:-A-Multi-inst...
Post a Comment
Read more

Exporter of Reprints (Printed Material)

  What is Reprints? Reprints generally refer to copies of a previously published work. The meaning can vary slightly depending on the context: In Publishing (Books, Journals, Articles): • Reprints are additional printed copies of an article or book that has already been published. • Authors often request reprints of their scientific or medical journal articles to distribute to colleagues, conferences, or patients. • Book reprints are new print runs of a previously released edition, often without changes. Example • A doctor publishes a case report in a journal and requests 500 reprints to distribute at a medical conference. • A publisher prints a second batch of an already released novel — that’s a reprint. Use of Reprints Published article hard copy and reprints may be used to display the potential of the article at interviews, conferences, distribution to colleagues, seminars and other promotional activities, etc. Exporter of Reprints (Printed Material) We are an ex...
Post a Comment
Read more