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Aggregation Function of Basic Formed Blood Elements in Patients with Arterial Hypertension with Dyslipidemia, Refused of Hypolipidemic Treatment

Aggregation Function of Basic Formed Blood Elements in Patients withArterial Hypertension with Dyslipidemia, Refused of Hypolipidemic Treatment

*Corresponding author: Medvedev IN, Russian State Social University, st. V. Pika, 4, Moscow, Russia, Tel: +79102732263; E-mail: ilmedv1@yandex.ru

Citation: Skorjatina IA, Medvedev IN, et al. Aggregation Function of Basic Formed Blood Elements in Patients with Arterial Hypertension with Dyslipidemia, Refused of Hypolipidemic Treatment. Clin Image Case Rep J. 2019; 1(1): 103. 

Objective: To consider the dynamics of the aggregation properties of blood cells in patients with arterial hypertension with dyslipidemia, who consciously refused lipid-lowering treatment. Under observation were 34 patients with arterial hypertension of 1-2 degrees, risk 3 and dyslipidemia type IIb, middle age. The control group is represented by 26 healthy volunteers of a similar age. All patients were informed about the need for lipid-lowering treatment and, because of their own beliefs, they refused it. Antihypertensive therapy for all patients was carried out with enalapril 10 mg, two times a day. Registration of clinical and laboratory parameters was carried out at the beginning of the observation, after 6, 12, 18, 52 and 104 weeks of observation. As a result of a dynamic assessment of the considered parameters in the observed patients with arterial hypertension and dyslipidemia for 104 weeks, the stability of the lipid profile, the level of lipid peroxidation in plasma and blood cells was observed, keeping these indicators at the outcome level. The absence of lipid-lowering treatment in patients with arterial hypertension and dyslipidemia kept the high aggregation potential of red blood cells, platelets and neutrophilic leukocytes during all 104 weeks of observation due to the preservation of violations of the mechanisms of their implementation. 

Keywords: Arterial hypertension; Dyslipidemia; Aggregation activity; Blood cells; Refusal of lipid-lowering therapy

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Location: Russia

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