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Anaplastic Large Cell Lymphoma Involving the Bladder: Rare Involvement of a Rare Malignancy

Anaplastic Large Cell Lymphoma Involving the Bladder: Rare Involvement of a Rare Malignancy

*Corresponding author: David L Wenzler, Michigan State University College of Human Medicine, East Lansing, MI, USA, E-mail: dwenzler@urologist.org

Citation: David L Wenzler, Michael R, Raymond JW, et al. Anaplastic Large Cell Lymphoma Involving the Bladder: Rare Involvement of a Rare Malignancy. Clin Image Case Rep J. 2019; 1(1): 101. 

Anaplastic large cell lymphoma (ALCL) is a rare and unfortunately aggressive lymphohematopoietic malignancy. While it can affect a number of extranodal sites, genitourinary involvement is extremely uncommon, with only eleven reported cases in the literature. Here, we report a case study of a healthy 50-year-old male with no prior urologic history, presenting with chief complaint of gross hematuria. Non-contrast CT imaging demonstrated irregular contours within the bladder with mild hydronephrosis bilaterally, regional lymphadenopathy, and a lytic bone lesion, concerning for malignancy. The patient was taken for cystoscopy, and biopsies were obtained from what was immediately apparent to be a grossly invasive tumor. His hospital course was further complicated by acute-on-chronic renal failure in the setting of stable, non-obstructing hydronephrosis, requiring placement of bilateral nephrostomy tubes. Ultimately, a pathologic diagnosis of anaplastic lymphoma kinase (ALK)- negative ALCL was made, which is notably one of eleven cases of ALCL with primary bladder involvement and only the second of these cases that is ALK-negative.

Keywords: Anaplastic; Lymphoma; Bladder; Malignancy
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Location: Russia

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